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平成28年度 教室業績 著書・論文

  • 清水 正樹.
  • 全身型 JIA の診断や病態評価に有用なバイオマーカーは何か?
  • 分子リウマチ治療 Vol.9,No.2,p6-71,2016,04
  • (教室業績第2215号)
  • 和田 泰三.
  • 【小児の症候群】感染・免疫・アレルギー DiGeorge 症候群.
  • 小児科診療 Vol.79 増刊,p326,2016,04
  • (教室業績第2216号)
  • 作村 直人,伊川 泰広,清水 正樹,谷内江昭宏.
  • 乳児血管腫を契機に診断された PELVIS 症候群.
  • 日本小児科学会雑誌 Vol.120,No.5,p896-89,2016
  • (教室業績第2217号)
  • (岩崎 秀紀,藤田 修平,谷内 裕輔,久保 達哉:富山県立中央病院小児科), (永田 義毅,臼田 和生:富山県立中央病院内科(循環器),(仲岡 英幸,伊吹圭二郎,小澤 綾佳,廣野 恵一,市田 蕗子:富山大学医学部小児科), (畑崎 喜芳).
  • 心臓再同期療法を施行した LMNA 変異を伴う先天性筋ジストロフィーの1例(原 著論文/症例報告).
  • 日本小児循環器学会雑誌 Vol.32,No.3,p237-243,2016,05
  • (教室業績第2218号)
  • (Toshihiro Sawai : Shiga University of Medical Science Department of Pediatrics), Masaki Shimizu,(Tomoyuki Sakai), Akihiro Yachie.
  • Tubulointerstitial Nephritis and Uveitis Syndrome Associated With Human Papillomavirus Vaccine.
  • Journal of pediatric ophthalmology and strabismus. Vol.53,No.3,p190-1,2016 May 1.doi:10.3928/01913913-20160405-04.
  • (教室業績第2219号)
  • Masaki Shimizu,(Yutaka Saikawa: Department of Pediatrics, School of Medicine, Kanazawa Medical University, Uchinada, Japan), Akihiro Yachie.
  • Role of18-fluoro-2-deoxyglucose positron emission tomography in detecting acute inflammatory lesions of non-bacterial osteitis in patients with a fever of unknown origin : A comparative study of 18-fluoro-2-deoxyglucose positron emission tomography, bone scan, and magnetic resonance imaging.
  • Modern rheumatology. p1-5,2016Jun20[Epub ahead of print]
  • (教室業績第2220号)
  • Masaki Shimizu, Natsumi Inoue, Mao Mizuta, Yasuhiro Ikawa, Akihiro Yachie.
  • Leopard skin appearance of cutaneous polyarteritis nodosa on 18Ffluorodeoxyglucose positron emission tomography.
  • Rheumatology(Oxford). Vol.5,No.6,p1090,2016 Jun.doi:10.1093/ rheumatology/kew065.Epub2016Mar2.No abstract available.
  • (教室業績第2221号)
  • 和田 泰三.
  • 知っておきたい最新のアレルギー・免疫学用語 EDN(便中)(解説).
  • 日本小児アレルギー学会誌 Vol.30,No.2,p206-207,2016,06
  • (教室業績第2222号)
  • 清水 博之1,菅原 秀典1,神垣 佑1,清水 正樹2,森 雅亮2,3.
    1 横浜市立大学附属市民総合医療センター小児総合医療センター.
    2 金沢大学医薬保健研究域医学系小児科.
    3 東京医科歯科大学薬害監視学講座.
  • 高サイトカイン血症を合併したヒトメタニューモウイルス感染症の2例(原著論 文/症例報告).
  • 日本小児科学会雑誌 Vol.120,No.6,p10-106,2016,06
  • (教室業績第2223号)
  • 清水 正樹.
  • 【腎と透析診療指針2016】(第16章)腎不全 腸管出血性大腸菌感染症に続発する 溶血性尿毒症症候群(解説/特集).
  • 腎と透析 Vol.80 増刊,p527-530,2016,06
  • (教室業績第2224号)
  • 谷内江昭宏.
  • サイトカイン・プロファイリングによる Still 病・マクロファージ活性化症候群・ 血球貪食症候群の診断.
  • Medical Practice Vol.3,No.7,2016,07,01
  • (教室業績第2225号)
  • Natsumi Inoue, Mao Mizuta, Masaki Shimizu.
  • Clinical Usefulness of18F-fluorodeoxyglucose Positron Emission Tomography for Enthesitis-related Arthritis Diagnosis.
  • The Journal of rheumatology. Vol.43,No.7,p1434-5,2016Jul
  • (教室業績第2226号)
  • Taizo Wada,(Tadayuki Akagi : Department of Stem Cell Biology, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan).
  • Role of the Leucine Zipper Domain of CCAAT/ Enhancer Binding Protein- Epsilon(C/EBPε)in Neutrophil-Specific Granule Deficiency.
  • Critical ReviewsTM in Immunology . Vol .36,No .4,p349-358.2016.doi : 10.1615/CritRevImmunol.2017019385.
  • (教室業績第2227号)
  • (太田 和秀,山宮 麻里:国立病院機構金沢医療センター小児科),井上なつみ, (中村 太地,小幡 美智,篠崎 絵里,千田 裕美,井上 巳香),清水 正樹, (前馬 秀昭,酒詰 忍).
  • 食思不振,腎機能低下にて気付かれた特発性尿細管間質性腎炎の1女児例(原著論 文/症例報告).
  • 日本小児腎不全学会雑誌 Vol.36,p21-215,2016,07
  • (教室業績第2228号)
  • (Ikawa Y : Geneticsand MolecularBiology Branch , National Human Genome Research Institute (NHGRI), Bethesda, MD, USA; Departmentof Pediatrics, Kanazawa University Hospital, Kanazawa, Japan.), (Uchiyama T : Genetics and Molecular Biology Branch, National Human Genome Research Institute(NHGRI), Bethesda, MD, USA ; Department of Human Genetics, National Research Institute for Child Health and Development, Tokyo, Japan.), (Jagadeesh GJ : Genetics and Molecular Biology Branch, National Human Genome Research Institute(NHGRI), Bethesda, MD, USA.), (Candotti F : Genetics and Molecular Biology Branch, National Human Genome Research Institute (NHGRI), Bethesda, MD, USA; Division of Immunology and Allergy, University Hospital of Lausanne, Lausanne, Switzerland).
  • The long terminal repeat negative control region is a critical element for insertional oncogenesis after gene transfer into hematopoietic progenitors with Moloney murine leukemia viral vectors.
  • Gene therapy. Vol.23,No.1,p815-818,2016 Nov.doi:10.1038/gt.2016.51. Epub 2016 Aug 4.
  • (教室業績第2229号)
  • Naotoshi Sugimoto1,4, Shinji Miwa2, Hiroyuki Nakamura3, Hiroyuki Tsuchiya2, Akihiro Yachie4.
    1 Department of Physiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
    2 Department of Orthopedic Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
    3 Department of Public Health, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
    4 Department of Pediatrics, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
  • Protein Kinase A And Epac Activation by cAMP Regulates the Expression of Glial Fibrillary Acidic Protein in Glial Cells.
  • Archives of Biological Sciences. Vol.68,No.4,p795-801,2016
  • (教室業績第2231号)
  • (後藤 善則:金沢大学附属病院消化器内科),西村 良成,野原 淳,馬!新太郎, 藤木 俊寛,伊良部 仁,黒田 梨絵,荒木 来太,伊川 泰広,前馬 秀昭, 谷内江昭宏.
  • 小児急性リンパ性白血病患者の L-asparaginase 関連膵炎において重度脂質異常の 関与は軽微である(原著論文/症例報告).
  • 臨床血液 Vol.57,No.8,p94-98,2016,08
  • (教室業績第2232号)
  • Taizo Wada, Yusuke Matsuda, Tomoko Toma, Eiko Koizumi, Hiroyuki Okamoto, Akihiro Yachie.
  • Increased CD69 Expression on Peripheral Eosinophils from Patients with Food Protein-Induced Enterocolitis Syndrome.
  • International archives of allergy and immunology. Vol.170,No.3,p201- 5,2016.doi:10.159/04875.Epub 2016 Sep 6.
  • (教室業績第2223号)
  • (Hue Leu : Department of Pediatrics, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan ; Dan Phuong General Hospital , Hanoi , Vietnam), (Naotoshi Sugimoto : Department of Pediatrics, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan ; Department of Physiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.), Masaki Shimizu, Tomoko Toma, Taizo Wada, Kunio Ohta, Akihiro Yachie.
  • Tumor necrosis factor-α modifies the effects of Shiga toxin on glial cells.
  • International Immunopharmacology. Vol.38,p139-143,September2016
  • (教室業績第2234号)
  • (杉田 侑子,岡本 奈美,謝花幸祐譲,村田 卓士:大阪医科大学小児科学教室), (黒川 晃夫:大阪医科大学皮膚科学教室),(鴨井 良明,港 敏則:公立豊岡病院組合立豊岡病院小児科),清水 正樹,谷内江昭宏,(玉井 浩).
  • 発症早期にマクロファージ活性化症候群を呈した若年性皮膚筋炎の1例(原著論 文/症例報告).
  • 小児リウマチ Vol.7,No.1,p37-42,2016,09
  • (教室業績第2235号)
  • 岡本 奈美1,13,岩田 直美2,13,梅林 宏明3,13,大倉 有加4,13,金城 紀子5,13,国島 知子5,13,久保田知洋6,13,清水 正樹7,13,野澤 智8,13,安村 純子9,13, 森 雅亮10,13,武井 修治6,1,13,横田 俊平12,13.
    1 大阪医科大学大学院医学研究科泌尿生殖・発達医学講座小児科.
    2 あいち小児保健医療総合センター感染・免疫科.
    3 宮城県立こども病院総合診療科・リウマチ科.
    4 北海道大学大学院医学研究科小児科学分野.
    5 琉球大学大学院医学研究科育成医学.
    6 鹿児島大学大学院医歯学総合研究科小児科学.
    7 金沢大学医薬保健研究域医学系小児科.
    8 横浜市立大学大学院医学研究科発生成育小児医療学.
    9 広島大学大学院医歯薬保健学研究科小児科学.
    10 東京医科歯科大学大学院医歯学総合研究科生涯免疫難病学講座.
    1 鹿児島大学大学院保健学研究科.
    12 東京医科大学医学総合研究所小児難病部門.
    13 日本リウマチ学会小児リウマチ調査検討小委員会若年性特発性関節炎初期診療の手引き改定ワーキンググループ.
  • 「若年性特発性関節炎初期診療の手引き」改定のためのアンケート調査結果の検討 (原著論文).
  • 小児リウマチ Vol.7,No.1,p5-13,2016,09
  • (教室業績第2236号)
  • Ikawa Y, Fujita N, Yachi Y, Inoue N, Kato A, Kuroda M, Yachie A.
  • Cover Image: Life-threatening complications of jellyfish Chrysaora pacifica stings in a5-year-old child.
  • The British journal of dermatology. Vol.175,No.4,p837-8,2016 Oct.doi: 10.1/bjd.14856.
  • (教室業績第2237号)
  • Natsumi Inoue, Akira Sato, Yasuhiro Ikawa, Masaki Shimizu,(Masaki Okajima, Takumi Taniguchi : Intensive Care Unit, Kanazawa University Hospital, Kanazawa, Japan), Akihiro Yachie.
  • Successful treatment of exertional heat stroke using continuous plasma diafiltration.
  • Journal of clinical apheresis. Vol.31,No.5,p490-2.2016 Oct.doi:10.102/ jca.21439.Epub 2015 Nov 17.
  • (教室業績第2238号)
  • 伊川 泰広,西村 良成,(酒井 清祥:金沢大学附属病院小児外科), 野口 和寛,福田 正基,藤木 俊寛,馬瀬 新太郎,黒田 梨絵,荒木 来太, 前馬 秀昭,谷内江昭宏.
  • 中心静脈カテーテル挿入後経過中に静脈穿破をきたした2症例の経験 造影剤注入 によるカテーテル先端位置確認法の有用性(原著論文/症例報告).
  • 日本小児血液・がん学会雑誌 Vol.53,No.3,p273-276,2016,10
  • (教室業績第2239号)
  • (Hisashi Kaneda : Department of Pediatrics, Toyama City Hospital, Toyama, Japan), Masaki Shimizu, (Kazuhide Ohta : Department of Pediatrics, Kanazawa Medical Center, Kanazawa, Japan),(Katsumi Ushijima : Department of Pediatrics, Yokkaichi Municipal Hospital, Yokkaichi, Japan),(Yoshimitsu Gotoh : Kidney Center Pediatrics, Nagoya Daini Red Cross Hospital, Nagoya, Japan),(Kenichi Satomura : Department of Pediatric Nephrology and Metabolism, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Japan),(Takuhito Nagai : Department of Pediatric Nephrology, Aichi Children’s Health and Medical Center, Obu, Japan), (Mikiya Fujieda : Department of Pediatrics, Kochi Medical School, Kochi University, Nankoku, Japan), (Masashi Morooka : Department of Pediatrics, Fujita Health University, Toyoake, Japan),(Takuji Yamada),(Masayoshi Yamada, Naohiro Wada : Department of Pediatric Nephrology, Shizuoka Children’s Hospital, Shizuoka, Japan), (Mari Takaai, Yukiya Hashimoto : Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan),(Osamu Uemura).
  • Population pharmacokinetics of mizoribine in pediatric patients with kidney disease.
  • Clinicaland Experimental October Nephrology. Vol.20, Issue5, p757-763,2016
  • (教室業績第2240号)
  • 谷内江昭宏.
  • 【周産期とバイオマーカー-病態と最新の治療を知ろう】【新生児】病態・検査 HLH/レーダーチャート(解説/特集).
  • 周産期医学 Vol.46,No.1,p1383-1386,2016,1
  • (教室業績第2241号)
  • Yasuhiro Ikawa, Yusuke Yachi, Natsumi Inoue, Akiko Kato, Michiko Okajima, Akihiro Yachie.
  • Neonatal McCune-Albright Syndrome with Giant Cell Hepatitis.
  • The Journal of Pediatrics. Vol1. 78,November 2016,p298.2016 Nov;178:298. doi:10.1016/j.jpeds.2016.08.09.Epub 2016 Aug 31.
  • (教室業績第2242号)
  • Natsumi Inoue, Yasuhiro Ikawa, Akira Sato, Ayano Yokoi, Mondo Kuroda, (Kozo Nomura, Seisho Sakai, Hidehiro Tajima: Department of Gastroenterologic Surgery, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.),(Hiroko Ikeda : Department of Pathology, Kanazawa University Hospital, Kanazawa, Japan.), (Haruka Ebisu, Hiroshi Kawasaki : Department of Medical Neuroscience, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan; Brain/Liver Interface Medicine Research Center, Kanazawa University, Kanazawa, Japan.),(Tetsuo Ohta), Akihiro Yachie.
  • Immunostaining of Sulfatide-Storing Macrophages in Gallbladder of a Patient With Metachromatic Leukodystrophy.
  • (教室業績第2243号)
  • Mao Mizuta1,2, Masaki Shimizu1, Natsumi Inoue1, Kazuko Kasai2, Yasuo Nakagishi2, Tadamori Takahara3, Kiyoshi Hamahira4, Akihiro Yachie1.
    1 Department of Pediatrics , School of Medicine , Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan.
    2 Department of Pediatric Rheumatology, Hyogo Prefectural Kobe Children’s Hospital, Kobe, Hyogo, Japan.
    3 Department of Pediatrics, Hyogo Prefectural Amagasaki Medical Center, Amagasaki, Hyogo, Japan.
    4 Department of Pediatrics, Japanese Red Cross Society Himeji Hospital, Hyogo, Japan.
  • Serum ferritin levels as a useful diagnostic marker for the distinction of systemic juvenile idiopathic arthritis and Kawasaki disease.
  • Modern rheumatology. Vol.26,No.6,p929-932.2016 Nov.doi:10.3109/ 14397595.2016.159120.Epub2016Jul19.
  • (教室業績第2224号)
  • Kazuyuki Ueno1, Masaki Shimizu1,2, Akio Uchiyama3, Kiyoshi Hatasaki1.
    1 Department of Pediatrics, Toyama Prefectural Central Hospital, Toyama, Japan. 2 Department of Pediatrics , School of Medicine , Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan. 3 Department of Pathology, Toyama Prefectural Central Hospital, Toyama, Japan.
  • Fulminant respiratory failure due to progressive metastatic pulmonary calcification with no predisposing factors after successful renal transplantation : A case report.
  • Pediatric transplantation. Vol.20,No.8,p152-156.2016 Dec.doi:10.1/ petr.12829.Epub 2016 Sep 27.
  • (教室業績第2245号)
  • Mitsugu Yoneda1, Naotoshi Sugimoto2,3,4, Masanori Katakura4,5, Kentaro Matsuzaki4, Hayate Tanigami1, Akihiro Yachie3, Takako Ohno-Shosaku1, Osamu Shido4.
    1 Impairment Study, Graduate School of Medical Sciences, Kanazawa University
    2 Department of Physiology, Graduate School of Medical Sciences, Kanazawa University.
    3 Pediatrics, Graduate School of Medical Sciences, Kanazawa University.
    4 Department of Environmental Physiology, School of Medicine, Shimane University.
    5 Department of Nutritional Physiology, Faculty of Pharmaceutical Sciences, Josai University.
  • Theobromine up-regulates cerebral brain-derived neurotrophic factor and facilitates motor learning in mice.
  • The Journal of nutritional biochemistry. Vol.39,p10-16,2017 Jan.doi: 10.1016/j.jnutbio.2016.10.02.Epub 2016 Oct 8.
  • (教室業績第2246号)
  • (中村 美穂, 吉川 陽文, 岡島 正樹, 蜂谷聡明, 小池 康志, 谷口 巧: 金沢大学附属病院集中治療部).
  • 内減圧術が有効であった小児重症頭部外傷の1例.
  • 日本救急医学会雑誌 Vol.28,No.1,p9-15,2017 January
  • (教室業績第2247号)
  • Wada T, Toma T,(Yasui M, Inoue M, Kawa K: Department of Hematology/ Oncology, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan),(Imai K, Morio T : Department of Pediatrics, Tokyo Medical and Dental niversity, Tokyo, Japan), Yachie A.
  • Different Clinical Phenotypes in 2 Siblings With X-Linked Severe Combined Immunodeficiency.
  • Journal of investigational allergology & clinical immunology. Vol.26,No.1, p63-5,2016
  • (教室業績第2248号)
  • Shintaro Ono1, Tsubasa Okano1, Akihiro Hoshino1, Masakatsu Yanagimachi1,2, Kazuko Hamamoto3, Yozo Nakazawa4, Toshihiko Imamura5, Masaei Onuma6, Hidetaka Niizuma7, Yoji Sasahara7, Hiroshi Tsujimoto8, Taizo Wada9, Reiko Kunisaki10, Masatoshi Takagi1, Kohsuke Imai1, Tomohiro Morio1, Hirokazu Kanegane1.
    1 Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University.
    2 Department of Pediatrics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
    3 Department of Pediatrics, Hiroshima Red Cross Hospital, Hiroshima, Japan.
    4 Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
    5 Department of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
    6 Department of Hematology and Oncology, Miyagi Children’s Hospital, Sendai, Japan.
    7 Department of Pediatrics, Tohoku University School of Medicine, Sendai, Japan. 8 Department of Pediatrics, Wakayama Medical University, Wakayama, Japan.
    9 Department of Pediatrics, Institute of Medical, Pharmaceutical and Health Sciences, School of Medicine, Kanazawa University, Kanazawa, Japan.
    10 Inflammatory Bowel Disease Centre, Yokohama City University Medical Centre, Yokohama, Japan.
    11 Department of Community Pediatrics, Perinatal and Maternal Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
  • Hematopoietic Stem Cell Transplantation for XIAP Deficiency in Japan.
  • Journal of Clinical Immunology. January. Vol.37,Issue1,pp85-91,2017
  • (教室業績第2249号)
  • 伊良部 仁,伊川 泰広,高倉麻衣子,井上なつみ,佐藤 啓,(野村 晧三, 酒井 清祥,楯川 幸弘:金沢大学附属病院小児外科),谷内江昭宏.
  • 典型的な臨床症状を呈したにもかかわらず診断に苦慮した肥厚性幽門狭窄症の1 例.
  • 小児科臨床別冊 Vol.70,No.2,p259-264,2017,02
  • (教室業績第2250号)
  • Yasuhiro Ikawa, Ryosei Nishimura, Raita Araki, Kazuhiro Noguchi, Masahiro Muraoka, Masaki Fukuda, Toshihiro Fujiki, Rie Kuroda, Shintaro Mase, Hideaki Maeba, (Keiko Nomura: Department of Paediatrics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.), Akihiro Yachie.
  • Pathognomonic serum cytokine profiles identify life-threatening langerhans cell histiocytosis.
  • Vol.176,No.3,p495-497,2017 Feb.doi:10.1/bjh.13970.Epub 2016 Apr 7.
  • (教室業績第2251号)
  • Masaki Shimizu, Natsumi Inoue, Mondo Kuroda, Mao Mizuta,(Naotoshi Sugimoto : Department of Physiology, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan), (Hisashi Kaneda : Department of Pediatrics, Toyama City Hospital, Toyama, Japan.),(Kazuhide Ohta : Department of Pediatrics, Kanazawa Medical Center, Kanazawa, Japan.), Akihiro Yachie.
  • Angiopoietin-1 and -2 as markers for disease severity in hemolytic uremic syndrome induced by enterohemorrhagic Escherichia coli.
  • Clinical and experimental nephrology. Vol.21,No.1,p76-82,2017 Feb.doi: 10.107/s10157-016-1254-z. Epub2016Mar5.
  • (教室業績第2252号)
  • (Naotoshi Sugimoto : Department of Physiology, Graduate School of Medical Science, Kanazawa University), (Masanori Katakura, Kentaro Matsuzaki : Department of Environmental Physiology, School of Medicine, Shimane University), (Hiroyuki Nakamura : Department of Public Health Pediatrics, Graduate School of Medical Science, Kanazawa University), Akihiro Yachie,(Osamu Shido).
  • Capsaicin partially mimics heat in mouse fibroblast cells in vitro.
  • Naunyn-Schmiedeberg’s archives of pharmacology. Vol.390,No.3,p281- 289,2017 Mar.doi:10.107/s0210-016-131-6.Epub 2016 Dec 14.
  • (教室業績第2253号)
  • (Yumi Senda, Kazuhide Ohta : Department of Pediatrics, Kanazawa Medical Center, National Hospital Organization, Kanazawa, Japan.), Tadafumi Yokoyama, Masaki Shimizu, (Kengo Furuichi : Department of Nephrology and Laboratory Medicine, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan. ), ( Takashi Wada : Divisionof Blood Purification , Kanazawa University Hospital, Kanazawa, Japan.), Akihiro Yachie.
  • Microangiopathic antiphospholipid antibody syndrome due to anti - phosphatidylserine/prothrombin complex IgM antibody.
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  • (教室業績第2255号)
学位論文

  • Yuko Tasaki, Masaki Shimizu, Natsumi Inoue, Mao Mizuta, (Yasuo Nakagishi : Department of Pediatric Rheumatology, Hyogo Prefectural Kobe Children’s Hospital, Japan), Taizo Wada, Akihiro Yachie.
  • Disruption of vascular endothelial homeostasis in systemic juvenile idiopathic arthritis-associated macrophage activation syndrome: The dynamic roles of angiopoietin-1and -2.
  • Cytokine. Vol.80,p1-6,2016April doi:10.1016/j.cyto.2016.02.08.Epub 2016 Feb 2.
  • (教室業績第2214号)
  • Abstract
  • To assess the role of angiopoietin(Ang)-1 and Ang-2 and to investigate the clinical significance of serum levels of them in systemic juvenile idiopathic a r t h r i t i s ( s - J I A )- a s s o c i a t e d m a c r o p h a g e a c t i v a t i o n s y n d r o m e ( M A S ), w e determined these levels in51patients with s-JIA,1patients with polyarticular JIA(poly-JIA), 12 patients with virus associated hemophagocytic syndrome (VAHS),12patients with Kawasaki disease(KD), and15age-matched healthy controls(HC).The results were compared with clinical features of MAS. During the MAS phase, serum Ang-1levels were significantly decreased compared with those during the active and inactive phases. Serum Ang-2/1 ratio were significantly elevated during the MAS phase, compared with those during the active and inactive phases. There was a rapid increase in the Ang-2/1 ratio at the onset of MAS. Serum Ang-1 and the Ang-2/1 ratio significantly correlated with measures of disease activity, including AST and LDH. Ang-2/1 dysregulation was also observed in patients with VAHS, whereas not observed in most cases of KD. The homeostasis of vascular endothelial function by Ang-1and Ang-2 is disrupted in MAS. Serum Ang-1 levels and the Ang-2/1 ratio might represent promising indicators of disease activity for MAS.
  • Natsumi Inoue, Masaki Shimizu, (Shinichiro Tsunoda : Division of Rheumatology, Department of Internal Medicine, Hyogo, College of Medicine, Nishinomiya, Japan), (Mitsuhiro Kawano : Division of Rheumatology, Department of Internal Medicine, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan),(Masami Matsumura : Division of General Internal Medicine, Jichi Medical University Hospital, Shimotsuke, Japan), Akihiro Yachie.
  • Cytokine profile in adult-onset Still’s disease : Comparison with systemic juvenile idiopathic arthritis.
  • Clinical Immunology. Vol.169,p8-13,2016August doi:10.1016/j.clim.2016.05.010.Epub 2016 Jun 3.
  • (教室業績第2230号)
  • Abstract
  • To compare pro-inflammatory cytokine profiles and kinetics in patients with adult-onset Still’s disease(AOSD)to those in patients with systemic juvenile idiopathic arthritis(s-JIA), we analyzed serum cytokine concentrations in 3 patients with AOSD and7patients with s-JIA and compared them with clinical features. Patients with AOSD and s-JIA shared a common cytokine profile pattern of a significant increase in IL-18. Patients with AOSD were classified into two subgroups based on serum IL-6 and IL-18 levels. The number of patients with arthritis was significantly higher in the IL-6-dominant subgroup. The cytokine patterns associated with s-JIA and AOSD share common features, such as a significant and predominant increase in IL-18.Distinct IL-6-and IL-18-based cytokine profiles might be responsible for distinct clinical manifestations. The presence of two distinct subgroups in patients with both diseases further supports the view that s-JIA and AOSD share a disease category.